Neurotransmitter regulation of neural development: acetylcholine and nicotinic receptors.

Modulation of Basal Glutamatergic Transmission by Nicotinic Acetylcholine Receptors in Rat Hippocampal Slices

Objective(s) Nicotinic acetylcholine receptors (nAChRs) regulate epileptiform activity and produce a sustained pro-epileptogenic action within the hippocampal slices. In the present study, we investigated the effect of nAChRs on evoked glutamatergic synaptic transmission in area CA3 and CA1 of rat hippocampal slices to identify possible excitatory circuits through which activation of nAChRs pr...

Role of nicotinic acetylcholine and cannabinoid receptors in the regulation of neurotransmitter release in the central nervous system Doctoral Theses

NICOTINE MECHANISMS IN ALZHEIMER’S DISEASE Overview of Nicotinic Receptors and Their Roles in the Central Nervous System

Alzheimer’s disease is a complex disorder affecting multiple neurotransmitters. In particular, the degenerative progression is associated with loss within the cholinergic systems. It should be anticipated that both muscarinic and nicotinic mechanisms are affected as cholinergic neurons are lost. This review focuses on the basic roles of neuronal nicotinic receptors, some subtypes of which decre...

Microarray and Proteomics Analysis on Neurotransmitter ( Nicotinic Acetylcholine Cys Loop Receptor ) By using Bioinformatics Tools

Excessive inflammation and tumor-necrosis factor (TNF) synthesis causes morbidity and mortality in diverse human diseases including endotoxaemia, sepisis, rheumatoid arthritis and inflammatory bowel diseases. Highly conserved, endogenous mechanisms normally regulate the magnitude of innate responses and prevent excessive inflammation. The release of system, through the vagus nerve, can inhibit ...

Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemia-reperfusion injury rats

Objective(s): Paeoniflorin (PF) has anti-oxidation, anti-inflammation, anti-apoptosis, and neuroprotection pharmacological effects against ischemic injury. The aim of the present study was to investigate the neuroprotection mechanisms of PF in cerebral ischemia-reperfusion injury rats.Materials and Methods: We established an animal model of cerebral infarct by occlusion of the middle cerebral a...